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Thermo Fisher
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Image Search Results
Journal: Scientific Reports
Article Title: Selective clearance of monoclonal antibodies via the mannose receptor is dependent on glycan pairing
doi: 10.1038/s41598-026-40268-1
Figure Lengend Snippet: High-mannose glyco-pair resolved PK study overview. The high-mannose content of mAb2 was enriched by ConA chromatography. The mAb2 drug product was prepared for the single IV injection to rats. Serum was taken at different time points. After immunocapture purification, mAb2 samples were analyzed for the total mAb concentration by LC-MS/MS after trypsin digestion, and for the glyco-pair distribution by RPC-MS after Endo F3 digestion.
Article Snippet: For this, 200 mL of
Techniques: Chromatography, IV Injection, Purification, Concentration Assay, Liquid Chromatography with Mass Spectroscopy